B cell lymphoproliferation in spontaneously diabetic BB Wistar rats
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چکیده
منابع مشابه
Metabolism of palmitate in isolated working hearts from spontaneously diabetic "BB" Wistar rats.
Myocardial fatty acid metabolism was studied in spontaneously-diabetic "BB" Wistar rats. The study involved 4 groups: control Wistar rats, nondiabetic littermates of "BB" Wistar rats, insulin-treated diabetic "BB" rats, and diabetic "BB" rats in which insulin treatment was removed 24 hours prior to study (uncontrolled diabetes). Hearts were perfused for 30 minutes as isolated working hearts in ...
متن کاملSerum lipids and lipoprotein composition in spontaneously diabetic BB Wistar rats.
Serum lipid and lipoprotein composition in spontaneously diabetic BB Wistar rats, nondiabetic littermates, and control Wistar rats was studied to elucidate diabetes-related abnormalities of lipoprotein composition. Serum total triglycerides and pre-beta-lipoprotein concentrations of insulin-treated spontaneously diabetic BB and nondiabetic littermate rats were significantly higher than those of...
متن کاملIslet cell surface antibodies and lymphocyte antibodies in the spontaneously diabetic BB Wistar rat.
Plasma from 14 diabetic and 6 nondiabetic BB Wistar rats along with plasma from 6 non-BB Wistar rats was evaluated for the presence of islet cells surface antibodies (ICSA) and antibodies to spleen lymphocytes by the protein-A radioligand assay. Dispersed Wistar rat islet cells incubated with plasma from diabetic rats bound 4255 +/- 2208 cpm 125I-protein A/5 x 10(4) islet cells (mean +/- SD) co...
متن کاملElevated glutamine metabolism in splenocytes from spontaneously diabetic BB rats.
To investigate the metabolic fates of glutamine in splenocytes from the BB rat with spontaneous immunologically mediated insulin-dependent diabetes, freshly isolated cells were incubated in Krebs-Ringer Hepes buffer with 1.0 mM-[U-14C]glutamine and 0, 4 mM- or 15 mM-glucose. (1) The major products of glutamine metabolism in splenocytes from normal and diabetic rats were ammonia, glutamate, aspa...
متن کاملEncapsulation of porcine islets permits extended culture time and insulin independence in spontaneously diabetic BB rats.
The ability to culture porcine islets for extended times allows for both their functional assessment and the assurance of their microbiological safety prior to transplantation. We have previously shown that agarose-encapsulated porcine islets can be cultured for at least 24 weeks. In the current study, porcine islet agarose macrobeads cultured for up to 67 weeks were assessed for their ability ...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1982
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf00252852